The Role of Vitamin B12
Vitamin B12 is essential for many vital functions, including red blood cell formation, neurological function, and DNA synthesis. A deficiency in this crucial vitamin can lead to a range of health problems, from fatigue and weakness to more serious neurological and hematological issues.
Understanding TCN2
TCN2, or transcobalamin II, is a protein that plays a critical role in the transport of vitamin B12 from the blood to cells. Genetic variations in the TCN2 gene can affect the efficiency of this transport, potentially leading to B12 deficiency even when dietary intake is adequate.
Why Rule Out TCN2 Variants?
Chronic Health Issues: People with genetic variations in TCN2 may experience chronic health issues, including persistent fatigue, autoimmune disorders, and neurological symptoms. These symptoms can often be misattributed to other causes, delaying appropriate treatment.
Autoimmune Conditions: B12 deficiency has been linked to various autoimmune conditions. Proper transport and utilisation of B12 are crucial for immune system regulation, and TCN2 variations can disrupt this balance.
Fatigue: Chronic fatigue is a common symptom of B12 deficiency. If you experience unexplained fatigue, it is important to consider genetic testing for TCN2 variants to ensure effective B12 transport and utilisation.
What You Can Do
Genetic Testing: Consider undergoing genetic testing to determine if you have TCN2 variants. This can provide valuable insights into your body's ability to process and transport vitamin B12. The Smart DNA Advanced Pathways test provides this data (NB: not all genetic tests do).
Monitor B12 Levels: Regular monitoring of your B12 levels, especially if you have chronic health issues, can help ensure you maintain adequate levels for optimal health. Note however that serum blood B12 levels are not always a good indicator of cellular deficiency, especially if you have a TCN1 or TCN2 genetic polymorphism.
Awareness and understanding of the role of TCN2 in B12 transport for many people leads them to better management of their chronic health issues and improved overall well-being.
Vanessa Vanderhoek is a integrative & functional medicine nutritionist specialising in the gut microbiome, biochemistry and nutrigenomics. She helps people to regain their health by taking a “food as medicine” approach that's unique to their body. Vanessa is based in Australia and has clients around the world. Book an appointment online by clicking here.